Managing hypoglycaemia

Hypoglycaemia unawareness.

Hypoglycaemia is the most frequent and serious complication of insulin therapy and is three times more common in those who are intensively treated. Impaired awareness of hypoglycaemia is a major limitation to achieving tight diabetes. Asymptomatic biochemical hypoglycaemia occurs more frequently during routine blood glucose monitoring and this should alert the clinician that the individual is d...

Sulphonylureas and hypoglycaemia.

hypoglycaemia-stimulated gastric secretion

Insulin-induced hypoglycaemia leads to vagally mediated stimulation of gastric secretion (Hollander, 1946). Insulin-induced hypoglycaemia also produces a stress response mediated by the sympathetic nervous system (Cannon, McIver, and Bliss, 1924; von Euler and Luft, 1952; Duner, 1954; Cantu, Wise, Goldfien, Gullixson, Fischer, and Ganong, 1963). Adrenaline and l-noradrenaline reduce basal and s...

Artefactual hypoglycaemia: and audit.

CORRESPONDENCE Paradoxical severe decrease in serum HDL-cholesterol after treatment with a fibrate: reply by the authors We read the letter of Olukoga 1 (in response to our earlier paper 2) with interest and feel that it covers the area of fibrate induced hy-poalphalipoproteinaemia excellently. Unfortunately , we are not aware of a clear and unifying explanation as to why some patients exhibit ...

Falciparum malaria and hypoglycaemia.

Sir, I read with interest the case report of Shalev et al.} on falciparum malaria-induced hypoglycaemia, and I wish to suggest another possible and important mechanism in the pathogenesis of hypoglycaemia associated with falciparum malaria infection. Several recent studies have demonstrated elevated serum levels of tumour necrosis factor-a (TNF) in patients with falciparum malaria,2-6 where thi...